[Rhombotin 2, an LMO (LIM-only) family member that functions in hematopoiesis, is encoded by the LMO2 gene. With two LIM domains and a cysteine-rich motif, rhombotin 2 is part of a multi-protein transcription regulatory complex that includes GATA-1. LMO2 protein binds to the bHLH TAL1 protein and interacts with retinoblastoma binding protein-2, enhancing transcription. Chromosomal translocations involving LMO2 are associated with T-cell leukemias. (from OMIM 180385 and NCI) ( NCI )]
UMLS (NCI) C0250437 - Amino Acid, Peptide, or Protein
- Biologically Active Substance