Cytotoxic Lymphocyte Maturation Factor 2, p40
[This protein is a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggested the role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. (LocusLink) ( NCI )]
UMLS (NCI) C1099914IL12B
IL23, subunit p40
Interkeukin-12 beta chain
Interleukin 12, p40
Interleukin 12B
Interleukin-12B
Natural Killer Cell Stimulatory Factor-2
IL23, subunit p40
Interkeukin-12 beta chain
Interleukin 12, p40
Interleukin 12B
Interleukin-12B
Natural Killer Cell Stimulatory Factor-2
- Amino Acid, Peptide, or Protein
- Immunologic Factor
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