Ertapenem
[A 1-beta-methyl carbapenem and broad-spectrum beta-lactam antibiotic with bactericidal property. Ertapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, in particular PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition results in a weakening and subsequent lysis of the cell wall leading to cell death of Gram-positive and Gram-negative aerobic and anaerobic pathogens. This agent is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, cephalosporinases and extended-spectrum beta-lactamases. ( NCI )]
UMLS (NCI) C1120106ERTAPENEM PREPARATION
- Organic Chemical
- Antibiotic
Relation/PAR: [AM130] BETA-LACTAMS ANTIMICROBIALS, OTHER
Unclassified Ingredients
Unclassified Ingredients
Relation/CHD: ERTAPENEM 1 GM
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