clozapine

[tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent; binds several types of central nervous system receptors, and displays a unique pharmacological profile; it is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype, and also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity; agranulocytosis is a major adverse effect associated with administration of this agent. ( CSP )]

UMLS (CSP) C0009079

Organic Chemical
Pharmacologic Substance

Relation/PAR: benzodiazepine
Dibenzazepines
[CN300] SEDATIVES/HYPNOTICS
[CN709] ANTIPSYCHOTICS, OTHER

Relation/CHD: CLOZAPINE 100 MG
CLOZAPINE 25 MG

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