c-Jun Kinase 3
[The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. (LocusLink) ( NCI )]
UMLS (NCI) C1455843C-Jun N-Terminal Kinase 3
MAP Kinase 10
MAP Kinase P49 3F12
MAPK10
Stress Activated Protein Kinase Beta
Stress-Activated Protein Kinase JNK3
MAP Kinase 10
MAP Kinase P49 3F12
MAPK10
Stress Activated Protein Kinase Beta
Stress-Activated Protein Kinase JNK3
- Amino Acid, Peptide, or Protein
- Enzyme
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