- 1. TLR protein
- [activates signal transduction pathways that result in transcriptional regulation and stimulate immune function; activates innate immunity as well as stimulating the antigen-specific immune response and triggering the inflammatory response; conveys signals stimulated by factors such as lipopolysaccharides, bacterial lipoproteins, peptidoglycans and also CpG nucleic acids. ( CSP )] (UMLS (CSP) C0670896) =Amino Acid, Peptide, or Protein; Receptor =Cell Surface Receptor;
| - 7. TLR5
- [This gene plays a role in the mediation of cytokine production and immunity. ( NCI )] (UMLS (NCI) C1336637) TLR5 Gene;
Toll-Like Receptor 5 Gene =Gene or Genome ;
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- 2. TLR1
- [This gene is involved in pathogen recognition and in the activation of innate immunity. ( NCI )] (UMLS (NCI) C1366477) TLR1 Gene;
Toll-Like Receptor 1 Gene;
=Gene or Genome ;
| - 8. TLR6
- [Expressed in monocytes, CD11c+ immature dendritic cells, and dermal endothelial cells by human TLR6 Gene (TLR Family), 796-aa 92-kDa (precursor) type I membrane protein Toll-Like Receptor 6 contains a TIR domain and 13 LRR repeats. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. Bound extracellularly to TLR2, TLR6 mediates cellular response to fungi and bacterial lipoproteins MALP-2, STF, PSM, and OspA-L. TLR6 acts via MyD88 (TIR interaction) and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and the inflammatory response. (NCI) ( NCI )] (UMLS (NCI) C0768454) Toll-Like Receptor 6;
=Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor |
- 3. TLR2
- [This gene plays a role in pathogen recognition and mediates the host response to gram-positive bacteria and yeast. ( NCI )] (UMLS (NCI) C1336634) TLR2 Gene;
Toll-Like Receptor 2 Gene =Gene or Genome ;
| - 9. TLR6
- [This gene is involved in immune responses through nuclear factor kappa-B signal transduction. ( NCI )] (UMLS (NCI) C1336638) TLR6 Gene;
Toll-Like Receptor 6 Gene =Gene or Genome ;
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- 4. TLR3
- [Expressed most in placenta, pancreas, and CD11c+ immature dendritic leukocytes by human TLR3 Gene (TLR Family), 904-aa 104-kDa (precursor) type I membrane protein Toll-Like Receptor 3 contains a TIR domain and 22 LRR repeats. Likely involved in host viral defense, TLR3 recognizes viral dsRNA and has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR3 appears to act via MyD88 (TIR interaction) and TRAF6, leading to NF-Kappa-B activation and production of type I interferons. (NCI) ( NCI )] (UMLS (NCI) C1313494) Toll-Like Receptor 3;
=Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor | - 10. TLR7
- [This gene plays a role in receptor signaling and in innate immune responses. ( NCI )] (UMLS (NCI) C1336639) TLR7 Gene;
Toll-Like Receptor 7 Gene =Gene or Genome ;
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- 5. TLR3
- [This gene is involved in innate antiviral responses. ( NCI )] (UMLS (NCI) C1336635) TLR3 Gene;
Toll-Like Receptor 3 Gene =Gene or Genome ;
| - 11. TLR8
- [This gene plays a role in receptor signaling and in immune responses. ( NCI )] (UMLS (NCI) C1336640) TLR8 Gene;
Toll-Like Receptor 8 Gene =Gene or Genome ;
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- 6. TLR4
- [This gene is involved in the mediation of immune responses and in signal transduction events induced by lipopolysaccharide. ( NCI )] (UMLS (NCI) C1336636) TLR4 Gene;
Toll-Like Receptor 4 Gene =Gene or Genome ;
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