CD CD1 CD2 CD3 CD4 CD5 CD6 CD7 CD8 CD9 CDA CDB CDC CDD CDE CDG CDH CDI CDK CDL CDM CDN CDO CDP CDR CDS CDT CDV CDW
CDC2-Related Protein Kinase
[Cyclin-Dependent Kinase 2, encoded by the CDK2 gene, belongs to the CDKX subfamily of the Ser/Thr protein kinase family. This protein kinase is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. It is involved in promoting DNA synthesis and cell cycle progression. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene exist. Its N-terminal domain interacts with cyclins and C-terminal domain interacts with CSK1. (From LocusLink, OMIM and NCI) ( NCI )]
UMLS (NCI) C0108855- Amino Acid, Peptide, or Protein
- Enzyme
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