CD CD1 CD2 CD3 CD4 CD5 CD6 CD7 CD8 CD9 CDA CDB CDC CDD CDE CDG CDH CDI CDK CDL CDM CDN CDO CDP CDR CDS CDT CDV CDW
CDK2/Cyclin A-Associated Protein p45
[Expressed by human SKP2 Gene (F-Box Family) as 3 alternative isoforms, alpha (42-aa 48-kDa), beta (410-aa), and gamma (442-aa), S-Phase Kinase-Associated Protein 2 contains an F-box domain and 10 tandem LRR repeats. SKP2 acts as a substrate recognition component of the SCF E3 ubiquitin ligase complex, which mediates ubiquitination and proteasomal degradation of target proteins involved in cell cycle progression, signal transduction, and transcription. SKP2 interacts with CUL1, SKP1, and CKS1, and with the Cyclin A/CDK2 complex as an essential element of Cyclin A/CDK2 S-Phase Kinase. Involved in the G1/S transition, SKP2 specifically recognizes phosphorylated CDKN1B/p27KIP predominantly in S phase and interacts with S-phase p19SKP1. CDKN1B/p27KIP degradation also requires CKS1. (NCI) ( NCI )]
UMLS (NCI) C0381943- Amino Acid, Peptide, or Protein
- Biologically Active Substance
Buy website
Medical Clinic. Optician. Pharmacy. Physician. Travel Agency. Hotel reservation. Child Care. Education. Teachers. Lessons. Tests and Exams. Certification. Shopping Center. Store. Real Estate.Affordable prices from $100.
  |
home
