CASP5
[Caspase-5, encoded by the CASP5 Gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme has been shown to induce apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein, which required Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. (From LocusLink and NCI) ( NCI )]
UMLS (NCI) C0769345CASP5 Protein
Caspase 5, Apoptosis-Related Cysteine Protease
Caspase-5
Cysteine Protease
EC 3.4.22.-
ICE(rel)-III
ICH3
ICH-3 Protease
TY Protease
Caspase 5, Apoptosis-Related Cysteine Protease
Caspase-5
Cysteine Protease
EC 3.4.22.-
ICE(rel)-III
ICH3
ICH-3 Protease
TY Protease
- Amino Acid, Peptide, or Protein
- Enzyme
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