[An active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. (NCI04) ( NCI )]
UMLS (NCI) C0731033Calcium Folinate
Calcium Leucovorin
Calcium levoleucovorin
Citrovorum Factor
Factor, Citrovorum
Folinate Calcium
Folinic Acid Calcium Salt Pentahydrate
LEUCOVORIN CALCIUM
LEUCOVORIN CALCIUM PREPARATION
Levofolinate calcium
- Organic Chemical
- Pharmacologic Substance
- Vitamin
Relation/PAR: 5-Formyl-5,6,7,8-tetrahydrofolic Acid
Relation/CHD: LEUCOVORIN CALCIUM 200 MG
LEUCOVORIN CALCIUM 50 MG
LEUCOVORIN CALCIUM 100 MG
LEUCOVORIN CALCIUM 10 MG
LEUCOVORIN CALCIUM 15 MG
LEUCOVORIN CALCIUM 25 MG
LEUCOVORIN CALCIUM 5 MG
LEUCOVORIN CALCIUM 5 MG/ML
LEUCOVORIN CALCIUM 350 MG
LEUCOVORIN CALCIUM 3 MG/ML