CD CD1 CD2 CD3 CD4 CD5 CD6 CD7 CD8 CD9 CDA CDB CDC CDD CDE CDG CDH CDI CDK CDL CDM CDN CDO CDP CDR CDS CDT CDV CDW
CD130 Antigen
[Widely expressed (not restricted to IL6 responsive cells) by human IL6ST Gene (Type I Cytokine Receptor 2 Family), heterodimeric type I membrane protein (isoform 1) and secreted (isoform 2) Interleukin 6 Signal Transducer contains 5 fibronectin type III domains, an Ig-like C2-type domain, a BOX 1 motif required for JAK interaction/activation, and a WSXWS motif necessary for protein folding, intracellular transport, and cell-surface receptor binding. Part of cytokine receptor complexes, IL6ST is a signal transducer dependent on receptor binding for activation by many cytokines (IL6, CNTF, LIF, IL11, CT1, and OSM) that can utilize gp130 in signal transmission. IL6ST may regulate myocyte apoptosis and have a role in embryonic development. Isoform 2 is an autoantigen in rheumatoid arthritis but it is not specific to RA. (NCI) ( NCI )]
UMLS (NCI) C1366325gp130 Transducer Chain
IL6ST
Interleukin 6 Signal Transducer
Interleukin Receptor Beta Chain
Membrane Glycoprotein gp130
IL6ST
Interleukin 6 Signal Transducer
Interleukin Receptor Beta Chain
Membrane Glycoprotein gp130
- Amino Acid, Peptide, or Protein
- Receptor
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