[Encoded by human DDR1 Gene (PTK Family, Insulin Receptor Subfamily), 913-amino acid 101 kD (precursor) Epithelial Discoidin Domain Receptor 1, a type I membrane protein homolog of mouse Ptk3, is largely expressed in epithelial cells of kidney, lung, gastrointestinal tract, and brain. DDR1 exhibits extracellular Discoidin I motifs; GLY/PRO-rich domains likely required for ligand or substrate interaction; a F5/8 type C domain; and a novel N-terminal region with homology to a factor VIII domain. The C-terminal catalytic domain has type II receptor tyrosine kinase motifs. Neurotrophin TRKs - TRKA, TRKB, and TRKC - regulate development and survival of specific neuronal lineages. Activated by type I-VI collagens, NTRK4 may be a non-neuronal receptor for a NGF or involved in cell-cell interactions or cell adhesion. (from Swiss-Prot Q08345 and NCI) ( NCI )]
UMLS (NCI) C0294276 - Amino Acid, Peptide, or Protein
- Enzyme
- Receptor